Like smudging with sage, smudging with Palo Santo is all about covering the space in which you need a boost of purified energy and want to attract alllll the good stuff with intention.
Consider what it is you'd like to bring into the room (calm? compassion? good vibes only?) and kick out of it (anger, frustration, generally bad juju), then start waving your burning Palo Santo around the corners of the room. You might even smudge around your own body if your goal is to clean up the energy around you